N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester
CAS No.:1447950-15-3
Molecular Formula:C₃₀H₃₇N₃O₆
Molecular Weight:535.64
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

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Chemical Property of N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

Chemical Property:

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Technology Process of N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

There total 5 articles about N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1447950-12-0
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophan

: 2133-40-6
L-proline methyl ester monohydrochloride

: 1447950-15-3
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 16h;
DOI:10.1039/c3ob40979a

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1447950-15-3
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 1 h

2.1: sodium cyanoborohydride / methanol / 16 h

3.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 1.33 h

3.2: 16 h

4.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h

With sodium cyanoborohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1039/c3ob40979a

Reference yield:

: 42460-99-1
N-(4-methoxybenzyl)-L-tryptophan

: 1447950-15-3
N-(tert-butoxycarbonyl)-N-(4-methoxybenzyl)-L-tryptophanyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 1.33 h

1.2: 16 h

2.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1039/c3ob40979a