1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER

Base Information

• Chemical Name: 1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER
• CAS No.: 850567-55-4
• Molecular Formula: C14H18 B F O2
• Molecular Weight: 248.105
• Hs Code.: 2934999090
• Mol file: 850567-55-4.mol

Synonyms:1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER;1-(4-Fluorophenyl)vinylboronic acid, pinacol ester 97%;1-(4-Fluorophenyl)vinylboronicacid,pinacolester97%

Chemical Property of 1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER

Chemical Property:

• Vapor Pressure: 0.00749mmHg at 25°C
• Melting Point: 38-42
• Refractive Index: 1.486
• Boiling Point: 277.8°C at 760 mmHg
• Flash Point: 121.8°C
• PSA: 18.46000
• Density: 1.04g/cm³
• LogP: 3.47030
• Storage Temp.: Keep Cold

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Fluorophenyl)vinylboronicAcid,PinacolEster ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-Fluorophenyl)vinylboronic Acid, Pinacol Ester is a useful research reagent for organic synthesis and other chemical processes.

Technology Process of 1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER

There total 12 articles about 1-(4-FLUOROPHENYL)VINYLBORONIC ACID, PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-ethynyl-4-fluorobenzene (766-98-3) + bis(pinacol)diborane (73183-34-3) → 2-(1-(4-fluorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane (850567-55-4)

Guidance literature:

bis(pinacol)diborane; With C₂₉H₃₉ClCuN; sodium t-butanolate; In tetrahydrofuran; at 22 ℃; for 0.0833333h; Inert atmosphere;

1-ethynyl-4-fluorobenzene; In tetrahydrofuran; methanol; at 22 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.202106107

Reference yield: 80.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1195-66-0) → 2-(1-(4-fluorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane (850567-55-4)

Guidance literature:

1-ethynyl-4-fluorobenzene; With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 2h; Inert atmosphere;

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; at 0 - 80 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d0cc02549f

Reference yield: 60.0%

bis(pinacol)diborane (73183-34-3) + 1-fluoro-4-(1-iodovinyl)benzene → 2-(1-(4-fluorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane (850567-55-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium phenolate; triphenylphosphine; In toluene;

DOI:10.1016/j.tetasy.2012.05.004

upstream raw materials:

1-ethynyl-4-fluorobenzene

bis(pinacol)diborane

1-(4-fluorophenyl)ethanone

2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-fluorobenzophenone

C₁₃H₁₃BFNO₄

MIDA ((4-fluorophenyl)oxomethyl)boronate

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