N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Base Information

Chemical Name:N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
CAS No.:1346221-91-7
Molecular Formula:C₂₇H₃₃ClFN₇O
Molecular Weight:526.057
Hs Code.:

Synonyms:N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

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Chemical Property of N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

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Technology Process of N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

There total 7 articles about N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1229236-85-4
4-((6-chloro-3-(4-chloro-2-fluorobenzyl)-2-methylimidazo-[1,2-b]pyridazin-8-yl)methyl)morpholine

: 141459-53-2
1-tert-butyl-3-methyl-1H-pyrazol-5-amine

: 1346221-91-7
N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

: C₃₅H₄₇FN₁₀O

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water; for 40h; Inert atmosphere; Reflux; Large scale reaction;
DOI:10.1021/op200229j

Reference yield:

: C₁₉H₂₁ClFN₅O

: 141459-53-2
1-tert-butyl-3-methyl-1H-pyrazol-5-amine

: 1346221-91-7
N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether; In tert-Amyl alcohol; toluene; at 70 - 102 ℃; for 5h; Inert atmosphere;
DOI:10.1021/op400226m

Reference yield:

: 1229236-83-2
(4-chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholino-methyl)imidazo[1,2-b]pyridazin-3-yl)methanone

: 1346221-91-7
N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine

: C₃₅H₄₇FN₁₀O

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylsilane; trifluoroacetic acid / 27 h / 50 - 88 °C / Inert atmosphere; Large scale reaction

1.2: 50 °C / pH 10 - 11 / Large scale reaction

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene; water / 40 h / Inert atmosphere; Reflux; Large scale reaction

With triethylsilane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water;
DOI:10.1021/op200229j