141459-53-2

Basic information

• Product Name: 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE
• Synonyms: 5-AMINO-1-T-BUTYL-3-METHYLPYRAZOLE;2-TERT-BUTYL-5-METHYL-2H-PYRAZOL-3-YLAMINE;1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE;BUTTPARK 30\03-89;5-AMINO-1-tert-BUTYL-3-METHYLPYRAZOLE;5-AMino-1-tert-butyl-3-Methyl-1H-pyrazole;5-Methyl-2-tert-butyl-2H-pyrazol-3-ylamine
• CAS NO: 141459-53-2
• Molecular Formula: C₈H₁₅N₃
• Molecular Weight: 153.22
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Amines;Pyrazoles & Triazoles
• Mol File: 141459-53-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 65-67°C
• Boiling Point: 259.7°Cat760mmHg
• Flash Point: 110.9°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 0.0128mmHg at 25°C
• Refractive Index: 1.532
• PKA: 4.70±0.10(Predicted)
• CAS DataBase Reference: 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE(141459-53-2)
• EPA Substance Registry System: 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE(141459-53-2)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 141459-53-2(Hazardous Substances Data)

Usage

General Description

1-(tert-butyl)-3-methyl-1H-pyrazol-5-ylamine is a chemical compound with the molecular formula C9H16N2. It is a pyrazole derivative with a tert-butyl group attached to the nitrogen atom and a methyl group attached to one of the carbon atoms in the pyrazole ring. 1-(TERT-BUTYL)-3-METHYL-1H-PYRAZOL-5-YLAMINE is commonly used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has various applications in medicinal chemistry, particularly in the development of potential drug candidates. Additionally, this chemical may also be used as a building block for the synthesis of other complex organic molecules.

InChI:InChI=1/C8H15N3/c1-6-5-7(9)11(10-6)8(2,3)4/h5H,9H2,1-4H3

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 32064-67-8 tert-butylhydrazine 
• 7400-27-3 tertbutylhydrazine hydrochloride 

Downstream Products

• 1346221-91-7 N-(1-tert-butyl-3-methyl-1H-pyrazol-5-yl)-3-(4-chloro-2-fluorobenzyl)-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine 
• 1118787-47-5 6-cyclopropyl-1-(1,1-dimethylethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 
• 880488-73-3 6-bromo-4-(2-tert-butyl-5-methyl-2H-pyrazol-3-ylamino)-2-(4-tert-butyl-phenyl)-2H-phthalazin-1-one 
• 154911-07-6 6-benzyl-1-tert-butyl-3-methylpyrazolo<3,4-d><1,3>thiazin-4-one 
• 154911-08-7 1-tert-butyl-3-methyl-6-phenylpyrazolo<3,4-d><1,3>thiazin-4-one 
• 154910-97-1 N-(1-tert-butyl-3-methylpyrazol-5-yl)phenylthioacetamide 
• 154910-98-2 N-(1-tert-butyl-3-methylpyrazol-5-yl)thiobenzamide 
• 154910-96-0 N-(1-tert-butyl-3-methylpyrazol-5-yl)thioacetamide 
• 161153-66-8 N-(1-tert-butyl-3-methylpyrazol-5-yl)-4-bromothiobenzamide 
• 161153-67-9 N-(1-tert-butyl-3-methylpyrazol-5-yl)-4-chlorothiobenzamide 
• 161153-62-4 N-(tert-butyl-3-methylpyrazol-5-yl)-4-bromobenzamide 
• 161153-63-5 N-(1-tert-butyl-3-methylpyrazol-5-yl)-4-chlorobenzamide 
• 154910-88-0 N-(1-tert-butyl-3-methylpyrazol-5-yl)phenylacetamide 

Relevant articles and documents

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

The G protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) are a family of inward-rectifying potassium channels, and there is significant evidence supporting the roles of GIRKs in a number of physiological processes and as potential targets for numerous indications. Previously reported urea containing molecules as GIRK1/2 preferring activators have had significant pharmacokinetic (PK) liabilities. Here we report a novel series of 1H-pyrazolo-5-yl-2-phenylacetamides in an effort to improve upon the PK properties. This series of compounds display nanomolar potency as GIRK1/2 activators with improved brain distribution (rodent Kp > 0.6).

5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER -TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS

The present application relates to a series of substituted pyra- zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R1, R2, Ra, Rs

Development and a practical synthesis of the JAK2 inhibitor LY2784544

The route selection and process research and development of a practical synthesis for JAK2 inhibitor LY2784544 is described. The first-generation synthesis route, similar to that used in discovery for derivatization of a benzylic amine moiety, was 14 overall steps and possessed several steps that required extensive development for large-scale production. Route selection considerations led to a modified synthesis that utilized a novel vanadium-catalyzed carbon-carbon bond-forming arylation reaction for incorporation of the key benzylic morpholine moiety. A protecting group used to mask an amino pyrazole unit was modified from PMB to tert-butyl, resulting in a dramatic reduction in the overall length of the route. These two major changes resulted in an eight-step synthesis, which was six steps shorter than the first-generation synthesis. In the pilot plant, the new synthesis was scaled to produce >100 kg of LY2784544 in high yield and purity under GMP conditions. The overall development including the vanadium-catalyzed C-C bond-forming methodology, a ketone reductive deoxygenation, and a palladium-catalyzed amination is described.