N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

Base Information

Chemical Name:N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid
CAS No.:188908-41-0
Molecular Formula:C₄₇H₆₉N₃O₁₂
Molecular Weight:868.078
Hs Code.:

Synonyms:N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

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Technology Process of N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

There total 3 articles about N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 188908-40-9
(S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (R)-1-{[(S)-1-((R)-1-{[(S)-1-((R)-1-benzyloxycarbonyl-2-phenyl-ethoxycarbonyl)-3-methyl-butyl]-methyl-carbamoyl}-ethoxycarbonyl)-3-methyl-butyl]-methyl-carbamoyl}-2-phenyl-ethyl ester

: 188908-41-0
N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 3h; under 2327.17 - 2585.74 Torr;
DOI:10.1021/jm020482k

Reference yield:

: 157567-63-0
benzyl N-methyl-L-leucyl-3-phenyl-D-lactate

: 188908-41-0
N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / DIC; DMAP / CH₂Cl₂ / 20 °C

2: 81 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dacarbazine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k

Reference yield:

: 153052-70-1
benzyl N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactate

: 188908-41-0
N-Boc-N-methyl-L-leucyl-3-phenyl-D-lactyl-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / CF₃CO₂H / CH₂Cl₂ / 1 h / 25 °C

2: 52 percent / DIC; DMAP / CH₂Cl₂ / 20 °C

3: 81 percent / H₂ / Pd/C / ethanol / 3 h / 2327.17 - 2585.74 Torr

With dmap; hydrogen; dacarbazine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm020482k