5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Base Information

Chemical Name:5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide
CAS No.:1415091-10-9
Molecular Formula:C₁₉H₁₆F₅N₅O
Molecular Weight:425.361
Hs Code.:

Synonyms:5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Chemical Property of 5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Technology Process of 5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

There total 9 articles about 5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 1415091-10-9
5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / acetic acid / 20 - 25 °C

2.1: ethanol / 24 h / Reflux

3.1: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

5.1: hydrogenchloride; water / 1,4-dioxane

5.2: pH ~ 8

With hydrogenchloride; hydrazine hydrate; water; bromine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; acetic acid;

Reference yield:

: 95728-57-7
2-bromo-1-(4-trifluoromethylphenyl)propan-1-one

: 1415091-10-9
5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 24 h / Reflux

2.1: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

4.1: hydrogenchloride; water / 1,4-dioxane

4.2: pH ~ 8

With hydrogenchloride; hydrazine hydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1415089-73-4
2-methyl-3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]-pyrimidine

: 1415091-10-9
5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

3.1: hydrogenchloride; water / 1,4-dioxane

3.2: pH ~ 8

With hydrogenchloride; hydrazine hydrate; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane;