2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Base Information

Chemical Name:2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide
CAS No.:1415089-59-6
Molecular Formula:C₂₁H₁₈F₅N₅O₂
Molecular Weight:467.398
Hs Code.:

Synonyms:2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Chemical Property of 2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

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Technology Process of 2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

There total 11 articles about 2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1415091-10-9
5-(aminomethyl)-2-(difluoromethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

: 75-36-5
acetyl chloride

: 1415089-59-6
2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 1415091-08-5
tert-butyl ((6-(difluoromethyl)-5-((4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)carbamoyl)pyridin-3-yl)methyl)carbamate

: 1415089-59-6
2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 1,4-dioxane

1.2: pH ~ 8

2.1: triethylamine / dichloromethane

With hydrogenchloride; water; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

: 711-33-1
4-trifluoromethyl propiophenone

: 1415089-59-6
2-(difluoromethyl)-5-(acetamidomethyl)-N-(4-methyl-5-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / acetic acid / 20 - 25 °C

2.1: ethanol / 24 h / Reflux

3.1: hydrazine hydrate / ethanol / 0.5 h / 125 °C / microwave irradiation

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 60 °C

5.1: hydrogenchloride; water / 1,4-dioxane

5.2: pH ~ 8

6.1: triethylamine / dichloromethane

With hydrogenchloride; hydrazine hydrate; water; bromine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; acetic acid;