2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester

Base Information

• Chemical Name: 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester
• CAS No.: 863226-22-6
• Molecular Formula: C₃₇H₃₈N₄O₁₁
• Molecular Weight: 714.729
• Mol file: 863226-22-6.mol

Synonyms:2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester

Chemical Property of 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester

There total 10 articles about 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-methoxy-5-methyl-3-nitro-benzoyl chloride (923924-30-5) + 3-[3-(3-amino-2-methoxy-5-methyl-benzoylamino)-2-methoxy-5-methyl-benzoylamino]-2-methoxy-5-methyl-benzoic acid methyl ester → 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester (863226-22-6)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 5h;

DOI:10.1016/j.tet.2005.06.042

Reference yield:

methyl 2-methoxy-5-methyl-3-nitrobenzoate (863226-26-0) → 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester (863226-22-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 760 Torr

2: 98 percent / triethylamine / CHCl₃ / 5 h / 20 °C

3: 98 percent / hydrogen / Pd/C / tetrahydrofuran / 6 h / 50 °C / 760 Torr

4: 85 percent / triethylamine / CHCl₃ / 5 h / 20 °C

5: hydrogen / Pd/C / tetrahydrofuran / 8 h / 30 °C / 760 Torr

6: 82 percent / triethylamine / CHCl₃ / 5 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform;

DOI:10.1016/j.tet.2005.06.042

Reference yield:

5-Methylsalicylic acid (89-56-5) → 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester (863226-22-6)

Guidance literature:

Multi-step reaction with 9 steps

1: 95 percent / sulfuric acid / 24 h / Heating

2: 72 percent / nitric acid / H₂O / 24 h / 20 °C

3: 80 percent / potassum carbonate; 18-crown-6 / acetone / 36 h / 20 °C

4: 99 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 760 Torr

5: 98 percent / triethylamine / CHCl₃ / 5 h / 20 °C

6: 98 percent / hydrogen / Pd/C / tetrahydrofuran / 6 h / 50 °C / 760 Torr

7: 85 percent / triethylamine / CHCl₃ / 5 h / 20 °C

8: hydrogen / Pd/C / tetrahydrofuran / 8 h / 30 °C / 760 Torr

9: 82 percent / triethylamine / CHCl₃ / 5 h / 20 °C

With 18-crown-6 ether; sulfuric acid; hydrogen; nitric acid; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; water; acetone;

DOI:10.1016/j.tet.2005.06.042

upstream raw materials:

2-methoxy-5-methyl-3-nitro-benzoyl chloride

3-amino-2-methoxy-5-methyl-benzoic acid methyl ester

methyl 2-methoxy-5-methyl-3-nitrobenzoate

2-methoxy-5-methyl-3-nitrobenzoic acid

Downstream raw materials:

2-methoxy-3-(2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoylamino)-5-methyl-benzoic acid methyl ester