Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate

Base Information

• Chemical Name: Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate
• CAS No.: 863226-26-0
• Molecular Formula: C10H11NO5
• Molecular Weight: 225.201
• Hs Code.: 2918990090
• Mol file: 863226-26-0.mol

Synonyms:Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate;2-Methoxy-5-methyl-3-nitro-benzoic acid methyl ester

Chemical Property of Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate

Chemical Property:

• Melting Point: 47 °C
• Boiling Point: 365.9±37.0 °C(Predicted)
• PSA: 81.35000
• Density: 1.254±0.06 g/cm3(Predicted)
• LogP: 2.22160

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate

There total 3 articles about Methyl 2-methoxy-5-methyl-3-nitrobenzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 2-hydroxy-5-methyl-3-nitrobenzoate (67191-44-0) + methyl iodide (74-88-4) → methyl 2-methoxy-5-methyl-3-nitrobenzoate (863226-26-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

DOI:10.1021/ol802679p DOI:10.1021/ja100579z

Reference yield:

5-Methylsalicylic acid (89-56-5) → methyl 2-methoxy-5-methyl-3-nitrobenzoate (863226-26-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / sulfuric acid / 24 h / Heating

2: 72 percent / nitric acid / H₂O / 24 h / 20 °C

3: 80 percent / potassum carbonate; 18-crown-6 / acetone / 36 h / 20 °C

With 18-crown-6 ether; sulfuric acid; nitric acid; potassium carbonate; In water; acetone;

DOI:10.1016/j.tet.2005.06.042

Reference yield:

methyl 6-hydroxy-m-toluate (22717-57-3) → methyl 2-methoxy-5-methyl-3-nitrobenzoate (863226-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / nitric acid / H₂O / 24 h / 20 °C

2: 80 percent / potassum carbonate; 18-crown-6 / acetone / 36 h / 20 °C

With 18-crown-6 ether; nitric acid; potassium carbonate; In water; acetone;

DOI:10.1016/j.tet.2005.06.042

upstream raw materials:

methyl 2-hydroxy-5-methyl-3-nitrobenzoate

methyl iodide

5-Methylsalicylic acid

methyl 6-hydroxy-m-toluate

Downstream raw materials:

2-methoxy-5-methyl-3-nitro-benzoyl chloride

2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoic acid methyl ester

2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester

2-methoxy-3-(2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoylamino)-5-methyl-benzoic acid methyl ester