1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone

Base Information

• Chemical Name: 1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone
• CAS No.: 84864-21-1
• Molecular Formula: C₂₂H₁₇NO
• Molecular Weight: 311.383
• DSSTox Substance ID: DTXSID001257513

Synonyms:1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone;SCHEMBL10933688;DTXSID001257513;84864-21-1

Chemical Property of 1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone

Chemical Property:

• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 311.131014166
• Heavy Atom Count: 24
• Complexity: 433

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)N2C3=CC=CC=C3C=C2C4=CC=CC=C4

Technology Process of 1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone

There total 3 articles about 1-[4-(2-Phenyl-1H-indol-1-yl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.8%

2-phenyl-indole (948-65-2) + para-bromoacetophenone (99-90-1) → 1-(4-(2-phenyl-1H-indol-1-yl)phenyl)ethanone (84864-21-1)

Guidance literature:

With copper(I) oxide; potassium carbonate; In pyridine; at 175 ℃; for 24h;

DOI:10.1021/jm00359a015

Reference yield: 64.0%

2-phenyl-indole (948-65-2) + 4-Iodoacetophenone (13329-40-3) → 1-(4-(2-phenyl-1H-indol-1-yl)phenyl)ethanone (84864-21-1)

Guidance literature:

With sodium t-butanolate; In dimethyl sulfoxide; at 120 ℃; for 12h;

DOI:10.1016/j.jorganchem.2019.120970

Reference yield: 43.5%

para-bromoacetophenone (99-90-1) + 2-phenyl-3-H-indole (64109-88-2) → 1-(4-(2-phenyl-1H-indol-1-yl)phenyl)ethanone (84864-21-1)

Guidance literature:

With potassium carbonate; copper(II) oxide; In pyridine; at 175 ℃; for 24h;

DOI:10.1021/jm00362a020

upstream raw materials:

2-phenyl-indole

para-bromoacetophenone

2-phenyl-3-H-indole

4-Iodoacetophenone

Downstream raw materials:

2,4-Dioxo-4-[4-(2-phenyl-indol-1-yl)-phenyl]-butyric acid

3-Hydroxy-4-[4-(2'-phenyl-1-indolyl)phenyl]-3-pyrroline-2,5-dione

2-[4-(2-Phenyl-indol-1-yl)-phenyl]-acetamide

[4-(2-Phenyl-indol-1-yl)-phenyl]-acetic acid methyl ester

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