3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

Base Information

Chemical Name:3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone
CAS No.:219136-66-0
Molecular Formula:C₂₇H₄₆O₄Si
Molecular Weight:462.745
Hs Code.:

3-(2-benzyloxy-ethyl)-4-<i>tert</i>-butoxy-2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

Synonyms:3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

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Chemical Property of 3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

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Technology Process of 3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

There total 5 articles about 3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 219136-60-4
3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanol

: 219136-66-0
3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 ℃;
DOI:10.1016/S0040-4039(98)02067-X

Reference yield:

: 100-39-0
benzyl bromide

: 219136-66-0
3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, 0 deg C, 20 h

2: 5 percent aq. HCl / tetrahydrofuran / 4 h / Ambient temperature

3: DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C

With hydrogenchloride; dmap; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(99)00062-2

Reference yield:

: 155095-85-5
2-((4aS,5S,6S,8aS)-6-tert-Butoxy-2,2,5-trimethyl-hexahydro-benzo[1,3]dioxin-5-yl)-ethanol

: 219136-66-0
3-(2-benzyloxy-ethyl)-4-tert-butoxy-2-(tert-butyl-dimethyl-silanyloxymethyl)-3-methyl-cyclohexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0.5 h, 2.) DMF, 0 deg C, 20 h

2: 5 percent aq. HCl / tetrahydrofuran / 4 h / Ambient temperature

3: DMAP / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 30 min, 2.) CH₂Cl₂, 0 deg C

With hydrogenchloride; dmap; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0957-4166(99)00062-2