N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Base Information

• Chemical Name: N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester
• CAS No.: 130619-15-7
• Molecular Formula: C₃₀H₄₇N₅O₁₀
• Molecular Weight: 637.731

Synonyms:N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Chemical Property of N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

There total 6 articles about N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-benzyloxycarbonyl-D-alanine (26607-51-2) + L-A2Pr(Boc)-D-Orn(Boc)-OMe → N-(benzyloxycarbonyl)-D-alanyl-Nβ-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-Nδ-(tert-butoxycarbonyl)-D-ornithine methyl ester (130619-15-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1021/ja00029a031

Reference yield:

(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate (130581-87-2) → N-(benzyloxycarbonyl)-D-alanyl-Nβ-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-Nδ-(tert-butoxycarbonyl)-D-ornithine methyl ester (130619-15-7)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pt/C / methanol / 14 h / 760 Torr / Ambient temperature

2: 82 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC) / CH₂Cl₂ / 2.5 h / Ambient temperature

3: 99 percent / H₂ / 10percent Pd/C / methanol / 17 h / 760 Torr / Ambient temperature

4: 88 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / CH₂Cl₂ / 1.5 h / Ambient temperature

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; platinum on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja00029a031

Reference yield:

methyl (R)-2-amino-5-[(tert-butoxycarbonyl)amino]pentanoate (51186-41-5) → N-(benzyloxycarbonyl)-D-alanyl-Nβ-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-Nδ-(tert-butoxycarbonyl)-D-ornithine methyl ester (130619-15-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC) / CH₂Cl₂ / 2.5 h / Ambient temperature

2: 99 percent / H₂ / 10percent Pd/C / methanol / 17 h / 760 Torr / Ambient temperature

3: 88 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / CH₂Cl₂ / 1.5 h / Ambient temperature

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/ja00029a031

upstream raw materials:

N-benzyloxycarbonyl-D-alanine

di-tert-butyl dicarbonate

methyl (R)-2-amino-5-[(tert-butoxycarbonyl)amino]pentanoate

N-[(benzyloxy)carbonyl]-3-[(tert-butoxycarbonyl)amino]-L-alanine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 130619-15-7 N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send