(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

Base Information

Chemical Name:(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate
CAS No.:130581-87-2
Molecular Formula:C₁₉H₂₈N₂O₆
Molecular Weight:380.441
Hs Code.:

Synonyms:(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

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Chemical Property of (R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

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Technology Process of (R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

There total 1 articles about (R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 67-56-1
methanol

: C₁₉H₂₄N₂O₇

: 130581-87-2
(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

Guidance literature:: at 16 - 26 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 130581-87-2
(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

: 130619-15-7
N-(benzyloxycarbonyl)-D-alanyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pt/C / methanol / 14 h / 760 Torr / Ambient temperature

2: 82 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC) / CH₂Cl₂ / 2.5 h / Ambient temperature

3: 99 percent / H₂ / 10percent Pd/C / methanol / 17 h / 760 Torr / Ambient temperature

4: 88 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC*HCl) / CH₂Cl₂ / 1.5 h / Ambient temperature

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ja00029a031

Reference yield:

: 130581-87-2
(R)-methyl 2-(benzyloxycarbonylamino)-5-(tert-butoxycarbonylamino)pentanoate

: 130619-14-6
N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropionyl-N^δ-(tert-butoxycarbonyl)-D-ornithine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pt/C / methanol / 14 h / 760 Torr / Ambient temperature

2: 82 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (WSC) / CH₂Cl₂ / 2.5 h / Ambient temperature

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ja00029a031