[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

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Chemical Name:[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine
CAS No.:1588952-13-9
Molecular Formula:C₂₃H₂₃N₇O
Molecular Weight:413.482
Hs Code.:

Synonyms:[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

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Chemical Property of [4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

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Technology Process of [4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

There total 5 articles about [4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1589084-78-5
4-[5-methoxy-2-(2-phenylaminopyridin-4-yl)pyrido[3,4-d]pyrimidin-4-yl] piperazine-1-carboxylic acid tert-butyl ester

: 1588952-13-9
[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 33252-30-1
2-chloro-4-pyridinenitrile

: 1588952-13-9
[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 20 - 85 °C

2.1: triethylamine; dmap / N,N-dimethyl acetamide / 0.33 h / 20 °C / Sonication

2.2: 2.08 h / 20 °C / Sonication

2.3: 20 °C

3.1: sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; sodium methylate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 82673-73-2
3-amino-5-methoxypyridine-4-carboxylic acid

: 1588952-13-9
[4-(5-methoxy-4-piperazin-1-ylpyrido[3,4-d]pyrimidin-2-yl)pyridin-2-yl]phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 20 - 85 °C

2.1: triethylamine; dmap / N,N-dimethyl acetamide / 0.33 h / 20 °C / Sonication

2.2: 2.08 h / 20 °C / Sonication

2.3: 20 °C

3.1: sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; sodium methylate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium t-butanolate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide;