N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

Base Information

Chemical Name:N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide
CAS No.:159815-83-5
Molecular Formula:C₃₅H₄₃N₅O₅
Molecular Weight:613.757
Hs Code.:

N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

Synonyms:N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

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Chemical Property of N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

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Technology Process of N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

There total 10 articles about N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 624-83-9
methyl isocyanate

: 159815-82-4
N-[1-[[(2'-Amino)[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

: 159815-83-5
N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm970816j

Reference yield:

: 70680-21-6
4-methyl-2'-nitrobiphenyl

: 159815-83-5
N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-bromosuccinimide, AIBN / CCl₄ / 1.5 h / Heating

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 4 h

3: 90 percent / H₂ / 5percent Pd/C / methanol / 2068.6 Torr

4: 68 percent / CH₂Cl₂ / 18 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hydride; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane;
DOI:10.1021/jm970816j

Reference yield:

: 577-19-5
2-nitrophenyl bromide

: 159815-83-5
N-[ 1-[[2'-[(Methylaminocarbonyl)amino][1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-3-t-butoxycarbonylamino-3-methylbutanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 28.05 g / aq. NaOH, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / propan-2-ol; benzene / 3 h / Heating

2: N-bromosuccinimide, AIBN / CCl₄ / 1.5 h / Heating

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 4 h

4: 90 percent / H₂ / 5percent Pd/C / methanol / 2068.6 Torr

5: 68 percent / CH₂Cl₂ / 18 h / Ambient temperature

With sodium hydroxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hydride; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; isopropyl alcohol; benzene;
DOI:10.1021/jm970816j