70680-21-6

Basic information

• Product Name: 1,1'-Biphenyl, 4-methyl-2'-nitro-
• CAS NO: 70680-21-6
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Mol File: 70680-21-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,1'-Biphenyl, 4-methyl-2'-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Biphenyl, 4-methyl-2'-nitro-(70680-21-6)
• EPA Substance Registry System: 1,1'-Biphenyl, 4-methyl-2'-nitro-(70680-21-6)

Safety Data

• Hazardous Substances Data: 70680-21-6(Hazardous Substances Data)

Usage

Structure

A derivative of biphenyl with a methyl group at the 4th position and a nitro group at the 2nd position.

Physical state

Yellow crystalline solid

Solubility

Insoluble in water, soluble in organic solvents

Uses

a. Precursor in the synthesis of other organic compounds
b. Building block in the production of pharmaceuticals, dyes, and polymers

Potential applications

Pesticide or herbicide due to its chemical structure and properties

Upstream product

• 644-08-6 4-Methylbiphenyl 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 106-49-0 p-toluidine 
• 98-95-3 nitrobenzene 
• 106-38-7 para-bromotoluene 
• 552-16-9 ortho-nitrobenzoic acid 
• 29540-83-8 p-tolyl triflate 
• 577-19-5 2-nitrophenyl bromide 
• 5142-75-6 tri(p-tolyl)bismuth 
• 624-31-7 4-tolyl iodide 
• 7664-93-9 sulfuric acid 

Downstream Products

• 169188-17-4 2'-nitro-1,1'-biphenyl-4-carboxaldehyde 
• 14385-93-4 2-iodo-4'-methylbiphenyl 
• 1417334-76-9 C₂₂H₁₅N₃O₅S 
• 1428147-09-4 C₂₃H₁₇N₃O₅S 
• 3652-91-3 2-methyl-9H-carbazole 
• 114799-21-2 2-butyl-4-chloro-5-(methoxymethyl)-1-<<2'-(trifluoromethanesulfonamido)biphenyl-4-yl>methyl>imidazole 
• 114772-51-9 2-butyl-4-chloro-5-(methoxymethyl)-1-<(2'-nitrobiphenyl-4-yl)methyl>imidazole 
• 124750-43-2 2-butyl-4-chloro-5-(hydroxymethyl)-1-<(2'-nitrobiphenyl-4-yl)methyl>imidazole 
• 114772-70-2 1-<(2'-aminobiphenyl-4-yl)methyl>-2-butyl-4-chloro-5-(methoxymethyl)imidazole 
• 197440-07-6 2-Butyl-3-[2'-(pyrrolidin-1-ylazo)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one 
• 138402-25-2 2-Butyl-3-(2'-nitro-biphenyl-4-ylmethyl)-1,3-diaza-spiro[4.4]non-1-en-4-one 
• 197440-06-5 2-Butyl-3-(2'-iodo-biphenyl-4-ylmethyl)-1,3-diaza-spiro[4.4]non-1-en-4-one 
• 138402-26-3 3-(2'-Amino-biphenyl-4-ylmethyl)-2-butyl-1,3-diaza-spiro[4.4]non-1-en-4-one 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 

Relevant articles and documents

Integrating Organic Lewis Acid and Redox Catalysis: The Phenalenyl Cation in Dual Role

In recent years, merging different types of catalysis in a single pot has drawn considerable attention and these catalytic processes have mainly relied upon metals. However, development of a completely metal free approach integrating organic redox and organic Lewis acidic property into a single system has been missing in the current literature. This study establishes that a redox active phenalenyl cation can activate one of the substrates by single electron transfer process while the same can activate the other substrate by a donor-acceptor type interaction using its Lewis acidity. This approach has successfully achieved light and metal-free catalytic C-H functionalization of unactivated arenes at ambient temperature (39 entries, including core moiety of a top-selling molecule boscalid), an economically attractive alternative to the rare metal-based multicatalysts process. A tandem approach involving trapping of reaction intermediates, spectroscopy along with density functional theory calculations unravels the dual role of phenalenyl cation.

Decarboxylative biaryl synthesis in a continuous flow reactor

A practical protocol was developed that allows performing decarboxylative cross-coupling reactions in continuous flow reactors. Various biaryls were thus synthesized from aromatic carboxylic acids and aryl triflates using a Cu/Pd-catalyst system.

Preparation of unsymmetrical biaryls via palladium-catalyzed coupling reaction of aryl halides

The synthesis of unsymmetrical biaryls is achieved using Pd(OAc)2 as the catalyst. A great variety of aryl halides having electron withdrawing and electron donating functional groups in para, meta and ortho positions have been successfully coupled.