1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>

Base Information

• Chemical Name: 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>
• CAS No.: 171191-35-8
• Molecular Formula: C₅₃H₉₆ClO₁₆P
• Molecular Weight: 1055.76
• Mol file: 171191-35-8.mol

Synonyms:1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>

Chemical Property of 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>

There total 11 articles about 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-5-O-triethylsilyl-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate> (171191-34-7) → 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate> (171191-35-8)

Guidance literature:

With hydrogen fluoride; In tetrahydrofuran; acetonitrile; for 16h;

DOI:10.1016/0040-4020(95)00515-A

Reference yield:

D-myo-inositol (87-89-8) → 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate> (171191-35-8)

Guidance literature:

Multi-step reaction with 10 steps

1: 97 percent / TsOH

2: 49 percent / Lipase CES

3: 92 percent / MeONa

4: 94 percent

5: 84 percent / DCC

6: 100 percent

7: 73 percent / TsOH / ethane-1,2-diol

8: 96 percent / C₅H₅NHBr

9: 100 percent

10: 69 percent / aq. HF

With Lipase CES; hydrogen fluoride; sodium methylate; Pyridine hydrobromide; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In ethylene glycol;

DOI:10.1080/10426509608545155

Reference yield:

D-1,2-O-cyclohexylidene-myo-inositol (55123-25-6,1251832-23-1) → 1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate> (171191-35-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 94 percent

2: 84 percent / DCC

3: 100 percent

4: 73 percent / TsOH / ethane-1,2-diol

5: 96 percent / C₅H₅NHBr

6: 100 percent

7: 69 percent / aq. HF

With hydrogen fluoride; Pyridine hydrobromide; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In ethylene glycol;

DOI:10.1080/10426509608545155

upstream raw materials:

1D-2-chloroacetyl-6-O-(4-oxopentanoyl)-3,4-O-(tetraisopropyldisiloxane-1,3-diyl)-5-O-triethylsilyl-myo-inositol 1-<(1,2-di-O-octadecanoyl-sn-glyceryl) methyl phosphate>

D-myo-inositol

D-1,2-O-cyclohexylidene-myo-inositol

rac-1,2-O-cyclohexylidene-myo-inositol

Refernces

• 1、 Watanabe, Yutaka,Okazaki, Tadashi,Yamamoto, Takashi,Ozaki, Shoichiro. "Synthetic strategies based on phosphite chemistry for inositol phosphates and phospholipids". . p. 321 - 324. Retrieved 2007/10/03.