α,α-dihydroxyl diisopropyl malonate

Base Information

Chemical Name:α,α-dihydroxyl diisopropyl malonate
CAS No.:70841-85-9
Molecular Formula:C₉H₁₆O₆
Molecular Weight:220.222
Hs Code.:

Synonyms:α,α-dihydroxyl diisopropyl malonate

Suppliers and Price of α,α-dihydroxyl diisopropyl malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of α,α-dihydroxyl diisopropyl malonate

Chemical Property:

Melting Point:60 °C

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses As demonstrated by Laszlo Kürti′s lab, the sterically hindered di-isopropyl keto malonate hydrate (and 902594) are excellent N-umpolung reagents for both aliphatic and aromatic primary amines via a simple condensation reaction. The steric hindrance in ester moiety allows the preparation of the corresponding iminomalonates in high yield and lends these imines sufficient hydrolytic stability during the purification process. The N-alkyl as well as N-aryl iminomalonates act as singly N-electrophilic reagents towards strong C-nucleophiles such as alkyl- and arylmetals (e.g., Grignard reagents). Thus, unsymmetrical secondary amines may be readily preapred at low temperatures and in the absence of transition metal catalysts.

Technology Process of α,α-dihydroxyl diisopropyl malonate

There total 1 articles about α,α-dihydroxyl diisopropyl malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13195-64-7
diisopropyl malonate

: 70841-85-9
α,α-dihydroxyl diisopropyl malonate

: 73972-39-1
2-oxo-malonic acid diisopropyl ester

Guidance literature:: With ammonium cerium (IV) nitrate; In acetonitrile; at 0 - 20 ℃; for 4h; Overall yield = 72 %;
DOI:10.1016/j.tetlet.2014.01.145

Reference yield: 87.0%

: 70841-85-9
α,α-dihydroxyl diisopropyl malonate

: 104-94-9
4-methoxy-aniline

: diisopropyl 2-((4-methoxyphenyl)imino)malonate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 3h; Molecular sieve; Reflux; Dean-Stark; Inert atmosphere;
DOI:10.1021/jacs.7b05279

Reference yield: 81.0%

: 70841-85-9
α,α-dihydroxyl diisopropyl malonate

: 98-16-8
3-trifluoromethylaniline

: diisopropyl 2-((3-(trifluoromethyl)phenyl)imino)malonate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 3h; Molecular sieve; Reflux; Dean-Stark; Inert atmosphere;
DOI:10.1021/jacs.7b05279