1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline
CAS No.:1332881-33-0
Molecular Formula:C₂₃H₁₉FN₂O₂S
Molecular Weight:406.48
Hs Code.:

Synonyms:1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

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Technology Process of 1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

There total 2 articles about 1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1332881-39-6
7-bromo-1-(4-fluoro-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline

: 144104-59-6
1H-indole-5-boronic acid

: 1332881-33-0
1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; for 16h; Inert atmosphere; Reflux;

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 114744-51-3
7-bromo-1,2,3,4-tetrahydroquinoline

: 1332881-33-0
1-(4-fluoro-benzenesulfonyl)-7-(1H-indol-5-yl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 80 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Reflux

With pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 2: Suzuki Coupling;