N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide

Base Information

• Chemical Name: N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide
• CAS No.: 1261242-31-2
• Molecular Formula: C₂₆H₂₃FN₆O₃S
• Molecular Weight: 518.571
• Mol file: 1261242-31-2.mol

Synonyms:N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide

Chemical Property of N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide

There total 7 articles about N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

6-(4-fluorophenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole (815595-78-9) + 4'-Carbonyl-1',2'-dimethoxyphenyl-1,2-diaminoethane (847698-97-9) → N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide (1261242-31-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 80 ℃; for 8h;

DOI:10.1007/s00044-016-1529-7

Reference yield:

C19H22N2O5 (1370335-15-1) → N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide (1261242-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dimethyl sulfoxide;

DOI:10.5012/bkcs.2010.31.10.2854

Reference yield:

6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole (815595-77-8) → N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)-3,4-dimethoxybenzamide (1261242-31-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxone / methanol; water / 16 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

With oxone; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide;

DOI:10.5012/bkcs.2010.31.10.2854

upstream raw materials:

C₁₉H₂₂N₂O₅

6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

6-(4-fluorophenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

4'-Carbonyl-1',2'-dimethoxyphenyl-1,2-diaminoethane