6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

Base Information

• Chemical Name: 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole
• CAS No.: 815595-77-8
• Molecular Formula: C₁₆H₁₁FN₄S₂
• Molecular Weight: 342.421
• Mol file: 815595-77-8.mol

Synonyms:6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

Chemical Property of 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

There total 4 articles about 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

4-iodo-2-(methylthio)pyrimidine (1122-74-3) + 6-p-fluorophenylimidazo<2,1-b>thiazole (7025-29-8) → 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole (815595-77-8)

Guidance literature:

With caesium carbonate; triphenylphosphine; palladium diacetate; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 12h;

Reference yield: 37.0%

4-Chloro-2-methylthiopyrimidine (49844-90-8) + 6-p-fluorophenylimidazo<2,1-b>thiazole (7025-29-8) → 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole (815595-77-8)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

DOI:10.1007/s00044-016-1529-7

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 6-(4-fluorophenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole (815595-77-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 16 h / Reflux

2: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 80 °C

With palladium diacetate; caesium carbonate; triphenylphosphine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2015.03.065

upstream raw materials:

4-iodo-2-(methylthio)pyrimidine

6-p-fluorophenylimidazo<2,1-b>thiazole

α-bromo-4-fluoroacetophenone

2-bromo-4'-fluoroacetophenone

Downstream raw materials:

6-(4-fluorophenyl)-5-(2-(methylsulfonyl)pyrimidin-4-yl)imidazo[2,1-b]thiazole

1-(2-(4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-phenylurea

N-(2-((4-(6-(4-fluorophenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-yl)amino)ethyl)benzamide

C₂₅H₂₁FN₆OS