5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

Base Information

Chemical Name:5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride
CAS No.:1271949-56-4
Molecular Formula:C₁₇H₁₆ClFN₄OS*ClH
Molecular Weight:415.319
Hs Code.:

Synonyms:5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

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Chemical Property of 5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

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Technology Process of 5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

There total 4 articles about 5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1271949-54-2
5-chloro-pyridine-2-carboxylic acid [4-fluoro-3-(1-hydroxy-1-methyl-allyl)-phenyl]-amide

: 17356-08-0
thiourea

: 1271949-56-4
5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: With hydrogenchloride; In acetic acid; at 22 - 40 ℃; for 3.5h;

Reference yield:

: 67500-19-0
5'-Amino-2'-fluoroacetophenone

: 1271949-56-4
5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 2 h / 20 - 30 °C

2: diethyl ether; tetrahydrofuran / 4 h / -60 - -20 °C

3: hydrogenchloride / acetic acid / 3.5 h / 22 - 40 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; acetic acid;

Reference yield:

: 128073-03-0
4-chloronicotinoyl chloride

: 1271949-56-4
5-chloro-pyridine-2-carboxylic acid [3-((E)-3-carbamimidoylsulfanyl-1-methyl-propenyl)-4-fluoro-phenyl]-amide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 2 h / 20 - 30 °C

2: diethyl ether; tetrahydrofuran / 4 h / -60 - -20 °C

3: hydrogenchloride / acetic acid / 3.5 h / 22 - 40 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; diethyl ether; acetic acid;