(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

Base Information

Chemical Name:(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide
CAS No.:1271948-76-5
Molecular Formula:C₁₇H₁₆ClFN₄OS
Molecular Weight:378.858
Hs Code.:

Synonyms:(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

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Chemical Property of (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

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Technology Process of (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

There total 8 articles about (S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 86873-60-1
5-chloropicolinic acid

: 1075230-69-1
(S)-4-(5-amino-2-fluorophenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

: 1271948-76-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

Guidance literature:: With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.9b00309

Reference yield:

: 935999-02-3
5-chloro-pyridine-2-carboxylic acid [3-((S)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide

: 1271948-76-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

: 1271949-32-6
5-chloro-pyridine-2-carboxylic acid [3-((R)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide

Guidance literature:: With Chiralpak AD; In propan-1-ol; acetonitrile; Resolution of racemate;

Reference yield:

: 1271949-54-2
5-chloro-pyridine-2-carboxylic acid [4-fluoro-3-(1-hydroxy-1-methyl-allyl)-phenyl]-amide

: 1271948-76-5
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide

: 1271949-32-6
5-chloro-pyridine-2-carboxylic acid [3-((R)-2-amino-4-methyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetic acid / 3.5 h / 22 - 40 °C

2: trifluoroacetic acid; trifluorormethanesulfonic acid / 3 h / 0 - 22 °C

3: Chiralpak AD / acetonitrile; propan-1-ol / Resolution of racemate

With hydrogenchloride; trifluorormethanesulfonic acid; trifluoroacetic acid; In propan-1-ol; acetic acid; acetonitrile;