diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Base Information

Chemical Name:diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
CAS No.:314043-08-8
Molecular Formula:C₂₂H₂₆N₂O₆S
Molecular Weight:446.524
Hs Code.:

Synonyms:diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

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Chemical Property of diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

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Technology Process of diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

There total 4 articles about diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24264-33-3
2-amino-3-carbethoxy-4,5,6,7-tetrahydrothieno[2,3-c]pyrido-6-carboxylic acid ethyl ester

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 314043-08-8
diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 24h;
DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 314043-08-8
diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 1.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 314043-08-8
diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine; sulfur / ethanol / 20 - 40 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

With morpholine; sulfur; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; 1: Gewald reaction;
DOI:10.1016/j.bmcl.2011.09.109