[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

Base Information

Chemical Name:[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]
CAS No.:1350735-70-4
Molecular Formula:C₂₉H₃₇N₆O₉P
Molecular Weight:644.621
Hs Code.:

[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

Synonyms:[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

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Chemical Property of [(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

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Technology Process of [(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

There total 26 articles about [(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350735-68-0
(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

: 1350735-69-1
C₂₉H₃₇N₆O₉P

: 1350735-70-4
[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

Guidance literature:: With Column: Chiralcel OD-H, 2 x 25 cm; In n-heptane; isopropyl alcohol; Resolution of diastereoisomers;

Reference yield:

: 1314972-33-2
(3R,4R,5R)-3,4-bis(benzyloxy)-5-(benzyloxymethyl)-3-methyl-tetrahydro-furan-2-ol

: 1350735-69-1
C₂₉H₃₇N₆O₉P

: 1350735-70-4
[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic anhydride / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

2.1: chloro-trimethyl-silane / tetrahydrofuran / 2 h / Inert atmosphere

2.2: 1 h / -78 °C

3.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 20 °C

3.2: 0 °C

4.1: boron trichloride / dichloromethane / 1 h / -78 °C

4.2: -78 °C

5.1: 1-methyl-1H-imidazole; trimethyl phosphite / tetrahydrofuran / 1.5 h / 0 - 20 °C

6.1: N,N-dimethyl-formamide dimethyl acetal / acetonitrile / 1 h / 20 °C

6.2: 48 h / 20 °C

7.1: Column: Chiralcel OD-H, 2 x 25 cm / isopropyl alcohol; n-heptane / Resolution of diastereoisomers

With 1-methyl-1H-imidazole; trimethyl phosphite; chloro-trimethyl-silane; boron trifluoride diethyl etherate; acetic anhydride; boron trichloride; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; n-heptane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1191237-41-8
C₂₈H₃₂O₅

: 1350735-69-1
C₂₉H₃₇N₆O₉P

: 1350735-70-4
[(Sp)-isopropyl 2-((S)-(((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy) (phenoxy)phosphorylamino)propanoate]

Guidance literature:: Multi-step reaction with 8 steps

1.1: water; sulfuric acid; acetic acid / 8 h / 70 °C

2.1: acetic anhydride / dimethyl sulfoxide / 16 h / 20 °C / Inert atmosphere

3.1: chloro-trimethyl-silane / tetrahydrofuran / 2 h / Inert atmosphere

3.2: 1 h / -78 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 20 °C

4.2: 0 °C

5.1: boron trichloride / dichloromethane / 1 h / -78 °C

5.2: -78 °C

6.1: 1-methyl-1H-imidazole; trimethyl phosphite / tetrahydrofuran / 1.5 h / 0 - 20 °C

7.1: N,N-dimethyl-formamide dimethyl acetal / acetonitrile / 1 h / 20 °C

7.2: 48 h / 20 °C

8.1: Column: Chiralcel OD-H, 2 x 25 cm / isopropyl alcohol; n-heptane / Resolution of diastereoisomers

With 1-methyl-1H-imidazole; trimethyl phosphite; chloro-trimethyl-silane; sulfuric acid; boron trifluoride diethyl etherate; water; acetic anhydride; boron trichloride; acetic acid; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; n-heptane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; acetonitrile;