(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Base Information

Chemical Name:(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
CAS No.:1350735-68-0
Molecular Formula:C₂₉H₃₇N₆O₉P
Molecular Weight:644.621
Hs Code.:

(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Synonyms:(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Chemical Property of (2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

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Technology Process of (2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

There total 15 articles about (2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1350735-57-7
(2S)-isopropyl 2-((((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

: 79-31-2
isobutyric Acid

: 1350735-68-0
(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: (2S)-isopropyl 2-((((2R,3R,4R,5R)-5-(4-aminopyrrolo[1,2-f]-[1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate; With N,N-dimethyl-formamide dimethyl acetal; In acetonitrile; at 20 ℃; for 1h;

isobutyric Acid; With dicyclohexyl-carbodiimide; In acetonitrile; at 20 ℃; for 48h;

With water; trifluoroacetic acid; In acetonitrile; at 0 - 20 ℃; for 64h;

Reference yield:

: 1191237-49-6
1′-cyano-2′-C-methyl-4-aza-7,9-dideazaadenosine

: 1350735-68-0
(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-methyl-1H-imidazole; trimethyl phosphite / tetrahydrofuran / 1.5 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide dimethyl acetal / acetonitrile / 1 h / 20 °C

2.2: 48 h / 20 °C

With 1-methyl-1H-imidazole; trimethyl phosphite; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; acetonitrile;

Reference yield:

: 917567-08-9
(3R,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]-3-methyloxolan-2-one

: 1350735-68-0
(2S)-isopropyl 2-((((2R,3R,4R,5R)-3-isobutyroxy-5-(4-aminopyrrolo[1,2-f][1,2,4]triazin-7-yl)-5-cyano-4-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro-trimethyl-silane / tetrahydrofuran / 2 h / Inert atmosphere

1.2: 1 h / -78 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / 0 - 20 °C

2.2: 0 °C

3.1: boron trichloride / dichloromethane / 1 h / -78 °C

3.2: -78 °C

4.1: 1-methyl-1H-imidazole; trimethyl phosphite / tetrahydrofuran / 1.5 h / 0 - 20 °C

5.1: N,N-dimethyl-formamide dimethyl acetal / acetonitrile / 1 h / 20 °C

5.2: 48 h / 20 °C

With 1-methyl-1H-imidazole; trimethyl phosphite; chloro-trimethyl-silane; boron trifluoride diethyl etherate; boron trichloride; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; dichloromethane; acetonitrile;