5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

Base Information

Chemical Name:5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole
CAS No.:1307812-31-2
Molecular Formula:C₂₅H₁₉F₃N₂O₂
Molecular Weight:436.433
Hs Code.:

Synonyms:5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

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Chemical Property of 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

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Technology Process of 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

There total 9 articles about 5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.7%

: 1307812-30-1
(E)-4,4-dimethyl-6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime

: 104721-34-8
methyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate

: 1307812-31-2
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

Guidance literature:: (E)-4,4-dimethyl-6-vinyl-3,4-dihydronaphthalen-1(2H)-one oxime; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 0.333333h;

methyl 3-phenyl-4-(trifluoromethyl)isoxazole-5-carboxylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1307812-31-2
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / 1,2-dichloro-ethane / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile / 35 °C / sodium phosphate buffer

3.2: 20 °C

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 0.58 h / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

With N-chloro-succinimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; triethylamine; lithium diisopropyl amide; diazomethyl-trimethyl-silane; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 23203-51-2
6-methoxy-4,4-dimethyl-3,4-dihydronaphthalen-1(2H)-one

: 1307812-31-2
5,5-dimethyl-3-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-7-vinyl-4,5-dihydronaphtho-[1,2-c]isoxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 0 °C

2.1: pyridine / 3.58 h / 20 °C / Cooling with ice

3.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 - 100 °C / Sealed tube; Inert atmosphere

4.1: sodium acetate / methanol / 1.5 h / Reflux

5.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / 0 °C

5.2: 0.33 h / 0 °C

With sodium acetate; boron tribromide; lithium chloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane;