2-Methyl-3-hydroxy-6-iodopyridine

Base Information

• Chemical Name: 2-Methyl-3-hydroxy-6-iodopyridine
• CAS No.: 848952-39-6
• Molecular Formula: C6H6 I N O
• Molecular Weight: 235.024
• Hs Code.: 2933399090
• European Community (EC) Number: 872-689-3
• DSSTox Substance ID: DTXSID80479917
• Nikkaji Number: J2.150.064J
• Wikidata: Q82314281
• Mol file: 848952-39-6.mol

Synonyms:6-Iodo-2-methylpyridin-3-ol;848952-39-6;2-METHYL-3-HYDROXY-6-IODOPYRIDINE;MFCD11044376;3-Pyridinol, 6-iodo-2-methyl-;3-Hydroxy-6-iodo-2-methylpyridine;6-iodo-2-methylpyridine-3-ol;SCHEMBL3951147;DTXSID80479917;KJIFHCTXFFMUIH-UHFFFAOYSA-N;AMY30544;YIB95239;AKOS022190089;AS-54453;SY245043;CS-0134630;FT-0758665;S10163;EN300-6480549;A930113

Chemical Property of 2-Methyl-3-hydroxy-6-iodopyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.657
• Boiling Point: 370.006°C at 760 mmHg
• PKA: 10.02±0.10(Predicted)
• Flash Point: 177.574°C
• PSA: 33.12000
• Density: 1.968g/cm³
• LogP: 1.70020
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 234.94941
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

95% ^*data from raw suppliers

6-Iodo-2-methyl-pyridin-3-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)I)O

Technology Process of 2-Methyl-3-hydroxy-6-iodopyridine

There total 1 articles about 2-Methyl-3-hydroxy-6-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-methyl-3-pyridinol (1121-25-1,55780-69-3) → 6-iodo-2-methylpyridin-3-ol (848952-39-6)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃;

DOI:10.1016/j.bmcl.2006.10.057

Reference yield: 93.0%

benzyl bromide (100-39-0) + 6-iodo-2-methylpyridin-3-ol (848952-39-6) → 2-methyl-3-benzyloxy-6-iodopyridine (856165-76-9)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1016/j.bmcl.2006.10.057

Reference yield:

phenylboronic acid (98-80-6) + 6-iodo-2-methylpyridin-3-ol (848952-39-6) → 3-hydroxy-2-methyl-6-phenylpyridine

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 115 ℃; for 16h; Inert atmosphere;

upstream raw materials:

2-methyl-3-pyridinol

Downstream raw materials:

2-methyl-3-benzyloxy-6-iodopyridine

3-(5-benzyloxy-6-methyl-pyridin-2-yl)-acrylic acid tert-butyl ester

tert-butyl 3-(5-(5-(3-cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl)-6-methylpyridin-2-yl)propanoate