3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol

Base Information

• Chemical Name: 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol
• CAS No.: 1395093-25-0
• Molecular Formula: C₂₂H₂₆N₂O
• Molecular Weight: 334.461
• Mol file: 1395093-25-0.mol

Synonyms:3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol

Chemical Property of 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol

There total 6 articles about 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2,6-diisopropylphenyl)-2-(3-methoxy-5-methylphenyl)-1H-imidazole (1395093-24-9) → 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol (1395093-25-0)

Guidance literature:

With pyridine hydrochloride; at 190 ℃; for 4h; Inert atmosphere;

Reference yield:

1-methoxy-3-methyl-benzene (100-84-5) → 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol (1395093-25-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4,4'-di-tert-butyl-2,2'-bipyridine / (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 80 °C / Sealed vessel

2.1: cesium fluoride; copper(II) nitrate trihydrate / water; methanol / 100 °C / Sealed vessel

3.1: trimethylaluminum / toluene / 2 h / 20 °C / Cooling; Inert atmosphere

3.2: 70 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / isopropyl alcohol / 3 h / Reflux; Inert atmosphere

5.1: pyridine hydrochloride / 4 h / 190 °C / Inert atmosphere

With copper(II) nitrate trihydrate; trimethylaluminum; pyridine hydrochloride; sodium hydrogencarbonate; cesium fluoride; 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; In tetrahydrofuran; methanol; water; isopropyl alcohol; toluene;

Reference yield:

2,6-diisopropylbenzenamine (24544-04-5) → 3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenol (1395093-25-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trimethylaluminum / toluene / 2 h / 20 °C / Cooling; Inert atmosphere

1.2: 70 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / isopropyl alcohol / 3 h / Reflux; Inert atmosphere

3.1: pyridine hydrochloride / 4 h / 190 °C / Inert atmosphere

With trimethylaluminum; pyridine hydrochloride; sodium hydrogencarbonate; In isopropyl alcohol; toluene;

upstream raw materials:

2,6-diisopropylbenzenamine

3-methoxy-5-methylbenzonitrile

1-methoxy-3-methyl-benzene

2-(3-methoxy-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Downstream raw materials:

1-(2,6-diisopropylphenyl)-2-(3-(3-(1-(2,6-diisopropylphenyl)-1H-imidazol-2-yl)-5-methylphenoxy)phenyl)-1H-imidazole

2,2'-(oxybis(3-methyl-5,1-phenylene))bis(1-(2,6-diisopropylphenyl)-1H-imidazole)