(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Base Information

Chemical Name:(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine
CAS No.:130120-89-7
Molecular Formula:C₂₀H₂₃NO₄
Molecular Weight:341.407
Hs Code.:

Synonyms:(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

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Chemical Property of (2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Chemical Property:

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Technology Process of (2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

There total 13 articles about (2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (-)-(2R,3R)-1-(benzyloxycarbonyl)-2-(4-methoxybenzyl)-3-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)pyrrolidine

: 130120-89-7
(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jo981908z

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 130120-89-7
(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

2: 166 mg / lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C

3: 103 mg / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 3 h / -78 °C

4: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; lithium triethylborohydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; 1: Acylation / 2: Reduction / 3: Reduction / 4: deprotection;
DOI:10.1021/jo981908z

Reference yield:

: 220416-64-8
(-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

: 130120-89-7
(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

2: 166 mg / lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C

3: 103 mg / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 3 h / -78 °C

4: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; lithium triethylborohydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; 1: Acylation / 2: Reduction / 3: Reduction / 4: deprotection;
DOI:10.1021/jo981908z