(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole
CAS No.:1313491-66-5
Molecular Formula:C₂₅H₂₆NO₂P
Molecular Weight:403.461
Hs Code.:

Synonyms:(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

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Chemical Property of (4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

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Technology Process of (4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

There total 5 articles about (4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol

: 74-88-4
methyl iodide

: 1313491-66-5
(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: (4'S)-2-[2'-(2''-diphenylphosphanylphenyl)-4',5'-dihydro-oxazol-4'-yl]-propan-2-ol; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 24h;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 1313491-66-5
(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / methanol / 2.5 h / 0 °C

2.1: tetrahydrofuran; diethyl ether / 18 h / 0 - 20 °C

2.2: 0 °C / Saturated solution

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

4.1: tetrahydrofuran / 2 h / 0 °C

5.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

5.2: 24 h / 0 - 20 °C

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.02.021

Reference yield:

: 179117-11-4
(1'S)-2-fluoro-N-(2'-hydroxy-1'-hydroxymethyl-2'-methylpropyl)-benzamide

: 1313491-66-5
(4S)-4-(1'-methoxy-1'-methylethyl)-2-(2''-diphenylphosphanylphenyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 75 h / 20 °C

2.1: tetrahydrofuran / 2 h / 0 °C

3.1: potassium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3.2: 24 h / 0 - 20 °C

With potassium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.02.021