7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

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Chemical Name:7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione
CAS No.:329190-12-7
Molecular Formula:C₂₄H₁₇FN₄O₂S
Molecular Weight:444.489
Hs Code.:

7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidine-2-thione

Synonyms:7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

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Chemical Property of 7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

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Technology Process of 7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

There total 2 articles about 7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3288-04-8
1-isothiocyanato-2-methoxybenzene

: 328087-59-8
2-amino-6-(2-fluoro-phenyl)-4-furan-2-yl-nicotinonitrile

: 329190-12-7
7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

Guidance literature:: With pyridine; In 1,4-dioxane; at 150 ℃; for 22h;
DOI:10.1080/10426500008076330

Reference yield:

: 24090-00-4
(Z)-1-(2-Fluoro-phenyl)-3-furan-2-yl-propenone

: 329190-12-7
7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / 22 h / Heating

2: 81 percent / pyridine / dioxane / 22 h / 150 °C

With pyridine; ammonium acetate; In 1,4-dioxane; ethanol; 1: Michael reaction;
DOI:10.1080/10426500008076330

Reference yield:

: 329190-12-7
7-(2-fluoro-phenyl)-5-furan-2-yl-4-imino-3-(2-methoxy-phenyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidine-2-thione

: C₅₀H₃₇FN₄O₉S

Guidance literature:: Multi-step reaction with 2 steps

1: (NH₄)2SO₄ / toluene / 8 h / Heating

2: 10 h / 155 - 160 °C

With ammonium sulfate; In toluene;
DOI:10.1080/10426500008076330