3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole
CAS No.:1393119-45-3
Molecular Formula:C₁₅H₉BrCl₂F₃NOS
Molecular Weight:459.114
Hs Code.:

Synonyms:3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

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Technology Process of 3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

There total 3 articles about 3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393119-40-8
(E/Z)-1-(4-bromo-5-methylthiophen-2-yl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1393119-45-3
3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; at 20 ℃; for 18h;

Reference yield:

: 13679-74-8
2-Acetyl-5-methylthiophen

: 1393119-45-3
3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 4 steps

1: sodium acetate; bromine / water / 18 h / 20 °C

2: lithium hydride / tetrahydrofuran / 5 h / 60 °C

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

4: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

With hydroxylamine hydrochloride; bromine; sodium acetate; lithium hydride; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 36901-17-4
1-(4-bromo-5-methylthiophen-2-yl)ethan-1-one

: 1393119-45-3
3-(4-bromo-5-methylthiophen-2-yl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydride / tetrahydrofuran / 5 h / 60 °C

2: triethylamine; trifluoroacetic anhydride / dichloromethane / 18 h / 0 - 20 °C

3: hydroxylamine hydrochloride; sodium hydroxide / ethanol / 18 h / 20 °C

With hydroxylamine hydrochloride; lithium hydride; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;