ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

Base Information

Chemical Name:ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate
CAS No.:1421849-97-9
Molecular Formula:C₂₇H₂₈FN₃O₂S
Molecular Weight:477.603
Hs Code.:

Synonyms:ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

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Chemical Property of ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

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Technology Process of ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

There total 6 articles about ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.8%

: 1421848-75-0
ethyl 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetate

: 100-39-0
benzyl bromide

: 1421849-97-9
ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

Guidance literature:: ethyl 2-(2-(1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 4h;

Reference yield:

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 1421849-97-9
ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 14 h / 100 °C

1.2: 3 h / 80 °C

2.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

4.1: ethanol / 16 h / 80 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

5.2: 4 h / 0 - 20 °C

With Lawessons reagent; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 936084-44-5
ethyl 1-tert-butyl-5-(4-fluorophenyl)-1H-pyrazole-4-carboxylate

: 1421849-97-9
ethyl 2-(2-(1-(tert-butyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl)thiazol-4-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium chloride; benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 48 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 1.5 h / 50 °C

3.1: ethanol / 16 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 - 20 °C

4.2: 4 h / 0 - 20 °C

With Lawessons reagent; sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;