N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

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Chemical Name:N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate
CAS No.:1575817-63-8
Molecular Formula:CH₂O₂*C₃₀H₃₇F₂N₅O₂
Molecular Weight:583.679
Hs Code.:

Synonyms:N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

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Chemical Property of N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

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Technology Process of N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

There total 10 articles about N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575817-63-8
N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

3.1: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

4.1: zinc; ammonium chloride / methanol / 2 h / 50 °C

5.1: ethanol / 16 h / 20 °C / Inert atmosphere

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

7.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

8.1: toluene; tetrahydrofuran / 1 h / -30 - 20 °C / Inert atmosphere

8.2: 0.25 h / 60 °C

9.1: hydrogen bromide; acetic acid / 1 h / 0 - 20 °C

9.2: 5 °C / pH Ca_. 7 - 8

With hydrogen bromide; sodium tris(acetoxy)borohydride; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 64-18-6
formic acid

: 1575819-93-0
benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-(difluoromethyl)-benzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate

: 1575817-63-8
N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

Guidance literature:: benzyl (1-((1-acryloylpyrrolidin-2-yl)methyl)-2-(4-(difluoromethyl)-benzamido)-1H-benzo[d]imidazol-5-yl)methyl((S)-3,3-dimethylbutan-2-yl)carbamate; With hydrogen bromide; acetic acid; at 0 - 20 ℃; for 1h;

With sodium hydrogencarbonate; at 5 ℃; pH=Ca. 7 - 8;

formic acid;

Reference yield:

: 1575819-57-6
tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

: 1575817-63-8
N-(1-((1-acryloylpyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-yl)amino)methyl-1H-benzo[d]imidazol-2-yl)-4-(difluoromethyl)benzamide formate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane; water / 3 h / 10 - 20 °C

3.1: zinc; ammonium chloride / methanol / 2 h / 50 °C

4.1: ethanol / 16 h / 20 °C / Inert atmosphere

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

6.1: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

7.1: toluene; tetrahydrofuran / 1 h / -30 - 20 °C / Inert atmosphere

7.2: 0.25 h / 60 °C

8.1: hydrogen bromide; acetic acid / 1 h / 0 - 20 °C

8.2: 5 °C / pH Ca_. 7 - 8

With hydrogen bromide; sodium tris(acetoxy)borohydride; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; zinc; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;