(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

Base Information

Chemical Name:(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester
CAS No.:1137728-78-9
Molecular Formula:C₂₃H₂₃NO₅S
Molecular Weight:425.505
Hs Code.:

Synonyms:(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

Chemical Property:

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Technology Process of (R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

There total 1 articles about (R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 159305-96-1
4-(2-iodophenyl)but-3-yn-1-ol

: 211054-04-5
(R)-2-(Toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

: 1137728-78-9
(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In diethyl ether; at 20 ℃; for 12h; optical yield given as %ee; Inert atmosphere;
DOI:10.1039/b815176h

Reference yield: 93.0%

: 1137728-78-9
(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

: 124-63-0
methanesulfonyl chloride

: 1137728-80-3
C₂₄H₂₅NO₇S₂

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1039/b815176h

Reference yield:

: 1137728-78-9
(R)-5-[2-(4-hydroxy-but-1-ynyl)-phenyl]-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

: (R)-5-(2-but-3-en-1-ynyl-phenyl)-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

: (S)-5-(2-but-3-en-1-ynyl-phenyl)-2-(toluene-4-sulfonylamino)-pent-4-ynoic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; for 2h; optical yield given as %ee; Inert atmosphere;
DOI:10.1039/b815176h