(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

Base Information

Chemical Name:(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide
CAS No.:178361-89-2
Molecular Formula:C₁₉H₃₂N₂O₄Si
Molecular Weight:380.56
Hs Code.:

Synonyms:(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

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Chemical Property of (R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

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Technology Process of (R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

There total 1 articles about (R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: [(R)-(4-Allyloxy-3,5-dibromo-phenyl)-methylcarbamoyl-methyl]-carbamic acid tert-butyl ester

: 74-88-4
methyl iodide

: 178361-89-2
(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/0040-4039(96)00582-5

Reference yield: 89.0%

: 178361-89-2
(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

: 178361-88-1
(S)-N-[Bis-(4-methoxy-phenyl)-methyl]-2-[(2R,3R)-2-[(R)-2-(tert-butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-succinamic acid

: C₅₉H₈₀FN₇O₁₅Si

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/0040-4039(96)00582-5

Reference yield:

: 178361-89-2
(R)-2-[4-Allyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-phenyl]-2-amino-N-methyl-acetamide

: C₅₃H₆₅N₇O₁₅

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / EDC,HOBT / tetrahydrofuran / 0 °C

2: 93 percent / TBAF / CH₂Cl₂ / 0 °C

3: 70 percent / CsF / dimethylformamide / 48 h / 23 °C

With tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; cesium fluoride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00582-5