methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Base Information

Chemical Name:methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate
CAS No.:159693-15-9
Molecular Formula:C₁₃H₇ClF₅NO₃
Molecular Weight:355.648
Hs Code.:

Synonyms:methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

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Chemical Property of methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

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Technology Process of methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

There total 3 articles about methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 143706-83-6
methyl 4,4-difluoro-4-chloro-2-butynoate

: 159693-15-9
methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Guidance literature:: With sodium hydroxide; In dichloromethane; at -5 - 5 ℃; for 0.25h;
DOI:10.1021/jf00049a040

Reference yield: 68.0%

: 143706-83-6
methyl 4,4-difluoro-4-chloro-2-butynoate

: (Z)-N-hydroxy-4-(trifluoromethyl)benzimidoyl chloride

: 159693-15-9
methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

: methyl 4-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-5-isoxazolecarboxylate

Guidance literature:: With sodium hydroxide; In dichloromethane; at 20 ℃;
DOI:10.1002/jhet.5570400404

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 159693-15-9
methyl 5-(chlorodifluoromethyl)-3-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 68 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

With sodium hydroxide; N-chloro-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040