C₁₆H₁₈F₃N

Base Information

• Chemical Name: C₁₆H₁₈F₃N
• CAS No.: 1311205-18-1
• Molecular Formula: C₁₆H₁₈F₃N
• Molecular Weight: 281.321
• Mol file: 1311205-18-1.mol

Synonyms:C₁₆H₁₈F₃N

Chemical Property of C₁₆H₁₈F₃N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₈F₃N

There total 4 articles about C₁₆H₁₈F₃N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-cyclohexyl-1-methyl-1H-indole (172983-86-7) + (trifluoromethyl)trimethylsilane (81290-20-2) → C16H18F3N (1311205-18-1)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; palladium diacetate; cesium fluoride; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane; In 2,2,2-trifluoroethanol; acetonitrile; at 20 ℃; for 6h;

DOI:10.1002/chem.201100283

Reference yield:

indole (120-72-9) → C16H18F3N (1311205-18-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylsilane; trichloroacetic acid / toluene / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

2.2: 0 - 20 °C

3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; palladium diacetate; cesium fluoride; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane / 2,2,2-trifluoroethanol; acetonitrile / 6 h / 20 °C

With triethylsilane; 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; palladium diacetate; sodium hydride; cesium fluoride; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane; trichloroacetic acid; In 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

DOI:10.1002/chem.201100283

Reference yield:

3-cyclohexyl-1H-indole (100717-32-6) → C16H18F3N (1311205-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

1.2: 0 - 20 °C

2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; palladium diacetate; cesium fluoride; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane / 2,2,2-trifluoroethanol; acetonitrile / 6 h / 20 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; [bis(acetoxy)iodo]benzene; palladium diacetate; sodium hydride; cesium fluoride; bis[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-2-yl]methane; In 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.1002/chem.201100283

upstream raw materials:

indole

3-cyclohexyl-1-methyl-1H-indole

(trifluoromethyl)trimethylsilane

3-cyclohexyl-1H-indole