172983-86-7

Upstream product

• 1262588-92-0 3-cyclohexyl-2-(triethylsilyl)-1H-indole 
• 100717-32-6 3-cyclohexyl-1H-indole 
• 74-88-4 methyl iodide 
• 931-48-6 2-cyclohexylacetylene 
• 148991-61-1 triethylsilyl(cyclohexylethynyl)silane 
• 374071-91-7 C₁₅H₁₇N 
• 603-76-9 1-methylindole 
• 108-93-0 cyclohexanol 
• 108-94-1 cyclohexanone 
• 120-72-9 indole 

Downstream Products

• 1262588-67-9 3-cyclohexyl-2-(3-methoxyphenyl)-1-methylindole 
• 1311205-18-1 C₁₆H₁₈F₃N 

Relevant academic research and scientific papers

Palladium-catalyzed intermolecular C3 alkenylation of indoles using oxygen as the oxidant

A general and efficient palladium-catalyzed intermolecular direct C3 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio- and stereoselectivity. All products are E-isomers at the C3-position, and no Z-

Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons

3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C promoted the nucleophilic addition of indoles to the cyclohexanones, and the subsequent dehydration and Pd/C-catalyzed dehydrogenation produced the 3-arylindoles. The additive 2,3-dimethyl-1,3-butadiene worked as a hydrogen acceptor to facilitate the dehydrogenation step.

Redox chain reaction - Indole and pyrrole alkylation with unactivated secondary alcohols

Secondary role: Indole and pyrrole derivatives are alkylated with unactivated secondary aliphatic alcohols by a Bronsted acid-catalyzed redox chain reaction mechanism. Broad functional-group tolerance has been demonstrated and preliminary studies suggest that 1,4-reduction of a putative indolyl carbocation is the dominant mechanistic pathway. Copyright

Palladium-catalyzed oxidative trifluoromethylation of indoles at room Temperature

Incorporation of fluorine atoms into organic molecules significantly enhances many of their properties, such as solubility, metabolic stability, and bioavailability. Among organofluorine molecules, trifluoro ACHTUNGTRENUNGmethylated compounds play a unique and important role in agricultural and medicinal chemistry.[2] As a consequence, the exploitation of efficient methods to construct C-CF3 bond has received much attention.

Palladium-catalyzed indole, pyrrole, and furan arylation by aryl chlorides

The palladium-catalyzed direct arylation of indoles, pyrroles, and furans by aryl chlorides has been demonstrated. The method employs a palladium acetate catalyst, 2-(dicyclohexylphosphino)-biphenyl ligand, and an inorganic base. Electron-rich and electron-poor aryl chlorides as well as chloropyridine coupling partners can be used, and arylated heterocycles are obtained in moderate to good yields. Optimization of base, ligand, and solvent is required for achieving best results.