1-azido-4--2-butanone

Base Information

• Chemical Name: 1-azido-4--2-butanone
• CAS No.: 78520-73-7
• Molecular Formula: C₁₂H₁₃N₃O₄
• Molecular Weight: 263.253
• Mol file: 78520-73-7.mol

Synonyms:1-azido-4--2-butanone

Chemical Property of 1-azido-4--2-butanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-azido-4--2-butanone

There total 1 articles about 1-azido-4--2-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-bromo-4-2-butanone (72155-10-3) → 1-azido-4--2-butanone (78520-73-7)

Guidance literature:

With sodium azide; potassium iodide; In acetone; for 2h;

DOI:10.1021/jm00141a010

Reference yield: 82.0%

ethylene glycol (107-21-1) + 1-azido-4--2-butanone (78520-73-7) → 1-azido-4--2-butanone ethylene ketal (78520-74-8)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 6h; Heating;

DOI:10.1021/jm00141a010

Reference yield:

1-azido-4--2-butanone (78520-73-7) → diethyl-7,8-dihydro-11-oxahomoaminopterin

Guidance literature:

Multi-step reaction with 8 steps

1: 82 percent / p-toluenesulfonic acid monohydrate / benzene / 6 h / Heating

2: 93.5 percent / 0.5 N NaOH / acetonitrile / 18 h / Ambient temperature

3: N-methylmorpholine, isobutyl chloroformate / 1.) DMF, 20 min, 2.) DMF, RT, 18 h

4: H₂ / 5percent Pd/C / methanol / 18 h / 1292.9 Torr

5: 2.) N-methylmorpholine / 1.) methanol, reflux, 1 h, 2.) methanol, 2 h

6: 94.8 percent / 1N HCl, trifluoroacetic acid / 55 °C

7: sodium dithionite / dimethylformamide; H₂O / 0.5 h

8: 0.1N NaOH / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium dithionite; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetonitrile; benzene;

DOI:10.1021/jm00141a010

upstream raw materials:

1-bromo-4-2-butanone

Downstream raw materials:

1-azido-4--2-butanone ethylene ketal

1-azido-4-(p-carboxyphenoxy)-2-butanone ethylene ketal

diethyl N--L-glutamate ketal

11-oxahomofolic acid