9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

Base Information

Chemical Name:9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid
CAS No.:299158-67-1
Molecular Formula:C₂₃H₃₃NO₅
Molecular Weight:403.519
Hs Code.:

Synonyms:9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

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Chemical Property of 9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

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Technology Process of 9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

There total 1 articles about 9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 19125-34-9
1-phenylpiperidin-4-one

: 169822-66-6
3,3-Dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 299158-67-1
9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

Guidance literature:: 3,3-Dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 50 ℃; for 2h;

1-phenylpiperidin-4-one; In tetrahydrofuran; hexane; at 50 ℃; for 2h; Further stages.;
DOI:10.1002/1521-3765(20000818)6:16<2948::AID-CHEM2948>3.0.CO;2-0

Reference yield: 71.0%

: 299158-67-1
9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 299158-68-2
9-(1-Phenylpiperidin-4-ylidene)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane

Guidance literature:: With N,N-dimethylformamide dineopentyl acetal; In acetonitrile; Heating;
DOI:10.1002/1521-3765(20000818)6:16<2948::AID-CHEM2948>3.0.CO;2-0

Reference yield:

: 299158-67-1
9-(1-Phenyl-4-hydroxypiperidin-4-yl)-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 299158-70-6
4-(1-Phenylpiperidin-4-yl)cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / N,N-dimethylformamide dineopentyl acetal / acetonitrile / Heating

2: 100 percent / H₂ / 10percent Pd/C / tetrahydrofuran

3: 100 percent / aq. HCl / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; hydrogen; N,N-dimethylformamide dineopentyl acetal; 10percent Pd/C; In tetrahydrofuran; acetonitrile;
DOI:10.1002/1521-3765(20000818)6:16<2948::AID-CHEM2948>3.0.CO;2-0