2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

Base Information

Chemical Name:2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide
CAS No.:1365091-33-3
Molecular Formula:C₂₀H₂₀N₂O₄S
Molecular Weight:384.456
Hs Code.:

Synonyms:2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

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Chemical Property of 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

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Technology Process of 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

There total 3 articles about 2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.3%

: 1356089-38-7
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-2-methylpropionic acid

: 536-90-3,918666-97-4
m-Anisidine

: 1365091-33-3
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmcl.2012.01.085

Reference yield:

: 32454-35-6
2-(4-bromophenyl)-2-methylpropionic acid

: 1365091-33-3
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: phenyllithium / tetrahydrofuran; toluene / 0.08 h / -80 °C / Inert atmosphere

1.2: 0.33 h / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 20 °C

With benzotriazol-1-ol; phenyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2012.01.085

Reference yield:

: C₁₀H₁₀O₄S^(2-)*2Li⁽¹⁺⁾

: 1365091-33-3
2-[4-((E)-2-cyano-ethenesulfonyl)phenyl]-N-(3-methoxy-phenyl)isobutyramide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / water; methanol / 20 °C

1.2: 1 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / acetonitrile / 20 °C

With benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; acetonitrile;