N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide

Base Information

• Chemical Name: N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide
• CAS No.: 87433-16-7
• Molecular Formula: C₁₅H₁₇NO₂S
• Molecular Weight: 285.292
• Mol file: 87433-16-7.mol

Synonyms:N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide

Chemical Property of N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide

There total 5 articles about N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-methoxy-N-methyl-N,2,4,6-tetradeuteroaniline (87433-28-1) + 4-toluene-d7-sulfinyl chloride (87433-31-6) → N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide (87433-16-7)

Guidance literature:

With pyridine; In diethyl ether; Title compound not separated from byproducts; 1.) -78 deg C, 1 min, 2.) RT;

DOI:10.1021/jo00173a005

Reference yield:

N-Methyl-N-phenyl-p-toluolsulfinamid (33692-24-9) → N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide (87433-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂O / tetrahydrofuran; hexane / -78 deg C, 2 h then RT, 2 h

2: D₂O, 65percent Oleum / 2 h / Heating

3: 91 percent / pyridine / diethyl ether / 1.) -78 deg C, 1 min, 2.) RT

With pyridine; sulfuric acid; water; water-d2; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/jo00173a005

Reference yield:

(2)H8-toluene (2037-26-5) → N-(3-methoxy-2,4,6-trideuteriophenyl)-N-methylheptadeuterio-4-toluenesulfinamide (87433-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium sulfite

2: 46 percent / SOCl₂

3: 91 percent / pyridine / diethyl ether / 1.) -78 deg C, 1 min, 2.) RT

With pyridine; thionyl chloride; sodium sulfite; In diethyl ether;

DOI:10.1021/jo00173a005

upstream raw materials:

3-methoxy-N-methyl-N,2,4,6-tetradeuteroaniline

4-toluene-d7-sulfinyl chloride

⁽²⁾H₈-toluene

N-Methyl-N-phenyl-p-toluolsulfinamid