2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

Base Information

Chemical Name:2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate
CAS No.:1284206-83-2
Molecular Formula:C₁₈H₁₈O₅
Molecular Weight:314.338
Hs Code.:

Synonyms:2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

Suppliers and Price of 2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

There total 4 articles about 2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (+)-dimethyl [(1S)-1-phenylprop-2-en-1-yl](prop-2-yn-1-yl)-malonate

: 15226-74-1,61091-28-9,61117-58-6
dicobalt octacarbonyl

: 1284206-83-2
2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

Guidance literature:: (+)-dimethyl [(1S)-1-phenylprop-2-en-1-yl](prop-2-yn-1-yl)-malonate; dicobalt octacarbonyl; In dichloromethane; at 20 ℃; for 3.5h; Inert atmosphere;

With trimethylamine-N-oxide; silica gel; In dichloromethane; at 20 ℃; for 16h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/adsc.201000706

Reference yield:

: 7217-71-2
1-phenyl-2-propenyl acetate

: 108-59-8
malonic acid dimethyl ester

: 1284206-83-2
2,2-dimethyl (3S,3aR)-5-oxo-3-phenyl-1,2,3,3a,4,5-hexahydropentalene-2,2-dicarboxylate

: C₁₈H₁₈O₅

Guidance literature:: Multi-step reaction with 2 steps

1: bis(η3-allyl-μ-chloropalladium(II)); N-Trimethylsilylacetamide; potassium acetate; C39H44NO4PSi2 / dichloromethane / 2 h / 0 °C / Inert atmosphere; Schlenk technique

2: dichloromethane / 20 °C / Inert atmosphere; Schlenk technique

With bis(η3-allyl-μ-chloropalladium(II)); C₃₉H₄₄NO₄PSi₂; potassium acetate; N-Trimethylsilylacetamide; In dichloromethane;
DOI:10.1021/acscatal.9b01166