Technology Process of isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate
There total 6 articles about isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
8-methoxy-3,4-dihydro-1H-naphthalene-2,2-dicarboxylic acid tert-butyl ester;
With
diphenyl phosphoryl azide; triethylamine;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
2-methyl-propan-1-ol;
at 115 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: K2CO3 / dimethylformamide
2.1: LDA / tetrahydrofuran / 1 h / -78 °C
2.2: 4.7 g / tetrahydrofuran / 2 h
3.1: aq. LiOH / methanol / 18 h
4.1: (PhO)2PON3; Et3N / tetrahydrofuran / 2 h
5.1: 2.9 g / 1.5 h / 115 °C
With
lithium hydroxide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
4.1: Curtis rearangement;
DOI:10.1021/jm0491750
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: 4.7 g / tetrahydrofuran / 2 h
2.1: aq. LiOH / methanol / 18 h
3.1: (PhO)2PON3; Et3N / tetrahydrofuran / 2 h
4.1: 2.9 g / 1.5 h / 115 °C
With
lithium hydroxide; diphenyl phosphoryl azide; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol;
3.1: Curtis rearangement;
DOI:10.1021/jm0491750
