isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate

Base Information

Chemical Name:isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate
CAS No.:833489-37-5
Molecular Formula:C₂₁H₃₁NO₅
Molecular Weight:377.481
Hs Code.:
Mol file:833489-37-5.mol

Synonyms:isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate

Suppliers and Price of isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate

Chemical Property:

PSA：73.86000
LogP:4.03750

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate

There total 6 articles about isobutyl 2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydro-8-methoxynaphthalen-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-83-1
2-methyl-propan-1-ol

: 827023-42-7
8-methoxy-3,4-dihydro-1H-naphthalene-2,2-dicarboxylic acid tert-butyl ester

: 833489-37-5
2-isobutoxycarbonylamino-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid tert-butyl ester

Guidance literature:: 8-methoxy-3,4-dihydro-1H-naphthalene-2,2-dicarboxylic acid tert-butyl ester; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;

2-methyl-propan-1-ol; at 115 ℃; for 1.5h;

Reference yield:

: 32178-63-5
8-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 833489-37-5
2-isobutoxycarbonylamino-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / dimethylformamide

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 4.7 g / tetrahydrofuran / 2 h

3.1: aq. LiOH / methanol / 18 h

4.1: (PhO)2PON₃; Et₃N / tetrahydrofuran / 2 h

5.1: 2.9 g / 1.5 h / 115 °C

With lithium hydroxide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Curtis rearangement;
DOI:10.1021/jm0491750

Reference yield:

: 83781-72-0
3-carbomethoxy-5-methoxy-1,2,3,4-tetrahydronaphthalene

: 833489-37-5
2-isobutoxycarbonylamino-8-methoxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 4.7 g / tetrahydrofuran / 2 h

2.1: aq. LiOH / methanol / 18 h

3.1: (PhO)2PON₃; Et₃N / tetrahydrofuran / 2 h

4.1: 2.9 g / 1.5 h / 115 °C

With lithium hydroxide; diphenyl phosphoryl azide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; 3.1: Curtis rearangement;
DOI:10.1021/jm0491750