C₁₃H₁₃BrO₃

Base Information

• Chemical Name: C₁₃H₁₃BrO₃
• CAS No.: 1504595-20-3
• Molecular Formula: C₁₃H₁₃BrO₃
• Molecular Weight: 297.148
• Mol file: 1504595-20-3.mol

Synonyms:C₁₃H₁₃BrO₃

Chemical Property of C₁₃H₁₃BrO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₃BrO₃

There total 4 articles about C₁₃H₁₃BrO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one (100074-53-1) + ethylene dibromide (106-93-4) → C13H13BrO3 (1504595-20-3)

Guidance literature:

With triethylamine; In acetone; Reflux;

DOI:10.1016/j.bmc.2014.05.018

Reference yield:

phenylacetic acid (100074-40-6) → C13H13BrO3 (1504595-20-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice

2: triethylamine / acetone / Reflux

With sodium hydride; triethylamine; In tetrahydrofuran; acetone;

DOI:10.1016/j.bmc.2014.05.018

Reference yield:

4-tolylacetic acid (622-47-9) → C13H13BrO3 (1504595-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / water / pH 9 - 10

2: dimethyl sulfoxide / 25 °C

3: sodium hydride / tetrahydrofuran / 20 °C / Cooling with ice

4: triethylamine / acetone / Reflux

With sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; water; dimethyl sulfoxide; acetone;

DOI:10.1016/j.bmc.2014.05.018

upstream raw materials:

phenylacetic acid

3-(4-methylphenyl)-4-hydroxyfuran-2(5H)-one

ethylene dibromide

4-tolylacetic acid

Downstream raw materials:

7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

7-(4-(2-(3-(4-methylphenyl)furan-2(5H)-one-4-yloxy)ethyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Refernces