{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

Base Information

Chemical Name:{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane
CAS No.:184719-77-5
Molecular Formula:C₄₂H₇₀O₄Si
Molecular Weight:667.101
Hs Code.:

{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

Synonyms:{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

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Chemical Property of {2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

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Technology Process of {2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

There total 8 articles about {2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 106-95-6
allyl bromide

: 184719-76-4
(3R,5R,7R,8R,9S,10S,13R,14S,17R)-17-((R)-4-Benzyloxy-1-methyl-butyl)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-7-ol

: 184719-77-5
{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: With potassium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

Reference yield:

: 474-25-9
chenodeoxycholic acid

: 184719-77-5
{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / KOH / dimethylformamide / 8 h / 10 - 20 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 1 h / 50 °C

3: 85 percent / KOH / dimethylformamide / 3 h / -10 - 0 °C

4: aq. NaIO₄ / OsO₄ / diethyl ether / 4 h / Ambient temperature

5: 83 percent / NaBH₄ / diethyl ether; ethanol / 1 h / Ambient temperature

6: 95 percent / DMAP / CH₂Cl₂ / 4 h / Ambient temperature

7: 94 percent / KOH / dimethylformamide / 3 h / 0 °C

With dmap; potassium hydroxide; sodium tetrahydroborate; sodium periodate; lithium aluminium tetrahydride; osmium(VIII) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 100-39-0
benzyl bromide

: 184719-77-5
{2-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-7-Allyloxy-17-((R)-4-benzyloxy-1-methyl-butyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yloxy]-ethoxy}-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / KOH / dimethylformamide / 3 h / -10 - 0 °C

2: aq. NaIO₄ / OsO₄ / diethyl ether / 4 h / Ambient temperature

3: 83 percent / NaBH₄ / diethyl ether; ethanol / 1 h / Ambient temperature

4: 95 percent / DMAP / CH₂Cl₂ / 4 h / Ambient temperature

5: 94 percent / KOH / dimethylformamide / 3 h / 0 °C

With dmap; potassium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;