(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

Base Information

Chemical Name:(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide
CAS No.:88454-99-3
Molecular Formula:C₃₄H₅₀N₂O₁₀
Molecular Weight:646.778
Hs Code.:

Synonyms:(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

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Chemical Property of (2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

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Technology Process of (2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

There total 4 articles about (2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88454-97-1
(7S,8S)-7,8-bis((benzyloxy)methyl)-1,14-dichloro-3,6,9,12-tetraoxatetradecane

: 88454-99-3
(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaI / acetone; methanol / 14 h / Heating

2: 1.) TlOEt / DMF, 1.) roomtemp., 1/2 h, 2.) 60 deg C, 16 h

With thallium (I) ethoxide; sodium iodide; In methanol; acetone;
DOI:10.1021/jo00179a004

Reference yield:

: 88454-96-0
2-(2-{(1S,2S)-3-Benzyloxy-1-benzyloxymethyl-2-[2-(2-hydroxy-ethoxy)-ethoxy]-propoxy}-ethoxy)-ethanol

: 88454-99-3
(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / SOCl₂, pyridine / benzene / 14 h / Heating

2: 100 percent / NaI / acetone; methanol / 14 h / Heating

3: 1.) TlOEt / DMF, 1.) roomtemp., 1/2 h, 2.) 60 deg C, 16 h

With pyridine; thionyl chloride; thallium (I) ethoxide; sodium iodide; In methanol; acetone; benzene;
DOI:10.1021/jo00179a004

Reference yield:

: 88454-94-8,135821-34-0
1,4-Di-O-benzyl-2,3-bis-O-<2-<2-(2-tetrahydropyranyloxy)ethoxy>ethyl>-L-threitol

: 88454-99-3
(2R,3R,11R,12R)-N,N,N',N'-Tetramethyl-11,12-bis<(benzyloxy)methyl>-1,4,7,10,13,16-hexaoxacyclooctadecane-2,3-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / 5percent HCl / methanol / 2 h / Heating

2: 62 percent / SOCl₂, pyridine / benzene / 14 h / Heating

3: 100 percent / NaI / acetone; methanol / 14 h / Heating

4: 1.) TlOEt / DMF, 1.) roomtemp., 1/2 h, 2.) 60 deg C, 16 h

With pyridine; hydrogenchloride; thionyl chloride; thallium (I) ethoxide; sodium iodide; In methanol; acetone; benzene;
DOI:10.1021/jo00179a004