(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

Base Information

Chemical Name:(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one
CAS No.:1416509-68-6
Molecular Formula:C₂₃H₁₄ClFO
Molecular Weight:360.815
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

Suppliers and Price of (E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

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Technology Process of (E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

There total 3 articles about (E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 766-98-3
1-ethynyl-4-fluorobenzene

: 1247123-27-8
C₁₅H₁₀BrClO

: 1416509-68-6
(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

Guidance literature:: With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; In 1,4-dioxane; at 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1002/adsc.201200108

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1416509-68-6
(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

2: tri-tert-butyl phosphine; copper(l) iodide; diisopropylamine; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 20 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/adsc.201200108

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 1416509-68-6
(E)-3-(4-chlorophenyl)-1-(2-((4-fluorophenyl)ethynyl)phenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 3 h / 20 °C / Schlenk technique; Inert atmosphere

2: tri-tert-butyl phosphine; copper(l) iodide; diisopropylamine; bis(benzonitrile)palladium(II) dichloride / 1,4-dioxane / 20 °C / Inert atmosphere; Schlenk technique

With copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/adsc.201200108